FEATURES OF OCCUPATIONAL SAFETY ORGANIZATION IN MOLECULAR GENETICS LABORATORIES
DOI:
https://doi.org/10.31861/biosystems2026.01.187Keywords:
occupational safety, molecular genetics laboratory, biosafety, PCR, laboratory hazards, safety training, personal protective equipment (PPE)Abstract
The article analyzes the specific features of occupational safety management in molecular genetic laboratories operating under intensive workloads and develops practical recommendations for minimizing occupational risks to personnel. A comparative analysis of scientific literature, international regulatory documents, and legislative frameworks was conducted. The study found that occupational safety in modern molecular genetic laboratories has evolved from the formal compliance with safety regulations into a comprehensive risk management system integrating scientific, engineering, and environmental approaches. This transformation is driven by the implementation of advanced technologies, including next-generation sequencing (NGS), CRISPR/Cas genome editing, and automated analytical platforms, which introduce new categories of occupational hazards. An effective occupational safety system is based on the requirements of ISO 15189:2022, ISO 35001:2019, ISO 45001:2018, as well as the WHO Laboratory Biosafety Manual and the CDC/NIH Biosafety in Microbiological and Biomedical Laboratories (BMBL) guidelines. Personnel working in such laboratories are exposed to biological, chemical, physical, ergonomic, and psychosocial risks, which require differentiated control measures. A critical component of safe laboratory operation is strict functional zoning of premises, ensuring unidirectional movement of materials, personnel, and airflow. Another essential element of the occupational safety system is the development of a strong safety culture through staff training, safety briefings, competency assessment, and the implementation of standard operating procedures (SOPs). The continuous improvement of occupational safety systems in molecular genetic laboratories is achieved through regular internal audits and systematic analysis of incidents and near-misses using root cause analysis methodologies. The transition from reactive to preventive risk management through corrective and preventive actions (CAPA) is a key prerequisite for maintaining a high level of laboratory safety. The study also identified significant gaps in Ukrainian legislation regarding the regulation of specific risks associated with modern molecular genetic laboratories. The adaptation of national standards to the requirements of ISO 35001:2019 and updated WHO guidelines is an important prerequisite for harmonizing Ukraine’s biosafety system with international standards.
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